The kidneys play one of the most important roles in maintaining serum bicarbonate and acid-base balance. As kidney function declines, a decrease in serum bicarbonate level is common. 1 out of every 4 adults over 50 yrs has low serum bicarbonate levels. It is associated with increased muscle wasting, development or worsening of bone disease, progression of chronic kidney disease (CKD), and increased mortality.

Administering bicarbonates to individuals with CKD has been recommended and is associated with an improvement in kidney function and has long term benefits in slowing the progression of CKD.

Individuals with low sodium bicarbonate levels are more likely to manifest a 50% reduction in kidney function or end stage renal disease than those with higher bicarbonate levels.

Metabolic acidosis (low pH) is one of the most commonly encountered complications of Chronic Kidney Disease and believed to contribute to a number of sequelae, including bone disease, altered protein metabolism, skeletal muscle wasting and progressive Glomerular Filtration Rate (GFR) decrease.

Low serum bicarbonate levels have been reported to be an independent predictor of kidney function decline and mortality in patients with CKD.

pHAlo™ has the bicarbonates and minerals that your body needs to replenish what it loses with age or disease.

You can read these facts and more at the American Journal of Kidney Diseases and PubMed:

• Association of Serum Bicarbonate With Clinical Outcomes in CKD: Could an Increase in Serum Bicarbonate Be a Double-Edged Sword?
• Effect of Treatment of Metabolic Acidosis on Vascular Endothelial Function in Patients with CKD: A Pilot Randomized Cross-Over Study.
• Effect of oral alkali supplementation on progression of chronic kidney disease
• Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy.